Epigenetic differences in AD

In a recently published paper, Jose Sanchez-Mut and Johannes Gräff, together with a team from researchers in Barcelona, show that in the human Alzheimer's brain, important DNA methylation differences exist between grey and white matter, made up, respectively, of neurons and glia. Such differences have in the past been largely neglected. These findings pave the way towards a better understanding of aberrant epigenetic modifications that are relevant for Alzheimer’s disease, the most common form of neurodegeneration worldwide.