Label-Free Imaging of Cerebral β-Amyloidosis
© 2012 EPFL
Label-Free Imaging of Cerebral β-Amyloidosis with Extended-Focus Optical Coherence Microscopy.
"Researchers of the groups of Profs Patrick Fraering (Merck Serono Chair in Neuroscience) and Theo Lasser (Laboratoire d'optique biomédicale) demonstrate label-free imaging of cerebral beta-amyloidosis ex vivo and in a living model of Alzheimer’s disease using extended-focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides three-dimensional, high-resolution images of beta-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the Alzheimeric sample ex vivo. xfOCM also opens the possibility to perform minimally invasive studies of beta-amyloid pathology in vivo, without the use of labeling methods which potentially confound experimental findings."